Blar i forfatter "Gu, Yuexi"

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    • ATG9A protects the plasma membrane from programmed and incidental permeabilization. 

      Claude-Taupin, Aurore; Jia, Jingyue; Bhujabal, Zambarlal; Garfa-Traore, Meriem; Kumar, Suresh; da Silva, Gustavo Peixoto Duarte; Javed, Ruheena; Gu, Yuexi; Allers, Lee; Peters, Ryan; Wang, Fulong; da Costa, Luciana Jesus; Pallikkuth, Sandeep; Lidke, Keith A; Mauthe, Mario; Verlhac, Pauline; Uchiyama, Yasuo; Salemi, Michelle; Phinney, Brett; Tooze, Sharon A; Mari, Muriel C.; Johansen, Terje; Reggiori, Fulvio; Deretic, Vojo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-12)
      The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad intracellular distribution and is present in numerous compartments, including the plasma membrane (PM). The reasons for the distribution of ATG9A to the PM and its role at the PM are not understood. Here, we show that ATG9A organizes, in concert with IQGAP1, components of the ESCRT system and uncover cooperation ...

    • Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs 

      Gu, Yuexi; Abudu, Yakubu Princely; Kumar, Suresh; Bissa, Bhawana; Choi, Seong Won; Jia, Jingyue; Lazarou, Michael; Eskelinen, Eeva-Liisa; Johansen, Terje; Deretic, Vojo (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-18)
      Mammalian homologs of yeast Atg8 protein (mAtg8s) are important in autophagy, but their exact mode of action remains ill‐defined. Syntaxin 17 (Stx17), a SNARE with major roles in autophagy, was recently shown to bind mAtg8s. Here, we identified LC3‐interacting regions (LIRs) in several SNAREs that broaden the landscape of the mAtg8‐SNARE interactions. We found that Syntaxin 16 (Stx16) and its cognate ...

    • Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation 

      Kumar, Suresh; Gu, Yuexi; Abudu, Yakubu Princely; Bruun, Jack-Ansgar; Jain, Ashish; Farzam, Farzin; Mudd, Michal H.; Anonsen, Jan Haug; Rusten, Tor Erik; Kasof, Gary; Ktistakis, Nicholas; Lidke, Keith A; Johansen, Terje; Deretic, Vojo (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-28)
      Syntaxin 17 (Stx17) has been implicated in autophagosome-lysosome fusion. Here, we report that Stx17 functions in assembly of protein complexes during autophagy initiation. Stx17 is phosphorylated by TBK1 whereby phospho-Stx17 controls the formation of the ATG13<sup>+</sup>FIP200<sup>+</sup> mammalian pre-autophagosomal structure (mPAS) in response to induction of autophagy. TBK1 phosphorylates Stx17 ...